While CBD is generally well-tolerated by most individuals, there are a few potential side effects to be aware of. Some users may experience mild side effects such as dry mouth, dizziness, or drowsiness, especially when first starting out.While CBD is generally well-tolerated by most individuals, there are a few potential side effects to be aware of. Some users may experience mild side effects such as dry mouth, dizziness, or drowsiness, especially when first starting out.